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目的分析O型孕妇产前免疫球蛋白G(Immunoglobulin G,Ig G)血型抗体水平与新生儿溶血病(HDN)相关性。方法选取该院2400例O型Rh血型系统中Rh(D)阳性孕妇进行产前Ig G抗体效价检测,分娩后新生儿血型非O型,Rh血型系统中Rh(D)阳性,进行HDN三项检查。结果 2400名孕妇中Ig G抗体效价<64者1256例,抗体效价≥64者1144例。对2400例新生儿进行溶血病检测,其中703例发生HDN,1697例未发生HDN,HDN的总体发病率为29.3%。在孕妇产前抗体效价<64中有199例发生了HDN,其发病率为15.8%,相对于HDN的总体发病率小;在孕妇产前抗体效价≥64中,有504例发生了HDN,其发病率为44.1%,相对于HDN的总体发病率大,差异有统计学意义(P<0.05)。在产前抗体效价分别为64、128、256、512时,相对应的HDN的发病率为27.8%、37.1%、80.0%、100.0%。结论产前抗体效价越高,HDN发病率越高,且溶血三项皆为阳性的比例更高,O型孕妇产前Ig G抗体效价与HDN发病率成正相关。
Objective To analyze the correlation between the level of IgG in blood and the hemolytic disease (HDN) of newborn with type O pregnant women. Methods Rh (D) -positive pregnant women in 2400 O type Rh blood group were tested for IgM antibody titer. After delivery, the blood type was non-O type and the Rh type was Rh (D) positive. Check items. Results Among 2,400 pregnant women, IgG antibody titers were <64 in 1256 cases and antibody titer ≥64 in 1144 cases. 2400 cases of newborn hemolytic disease detection, of which 703 HDN occurred, 1697 cases of HDN did not occur, the overall incidence of HDN was 29.3%. HDN was present in 199 of prenatal antibody titers <64 in pregnant women, with a prevalence of 15.8%, relative to the overall incidence of HDN; in prenatal antibody titers ≥64 among pregnant women, 504 developed HDN , The incidence was 44.1%, relative to the overall incidence of HDN, the difference was statistically significant (P <0.05). When the prenatal antibody titers were 64, 128, 256, and 512 respectively, the corresponding incidence of HDN was 27.8%, 37.1%, 80.0% and 100.0%. Conclusion The higher the prenatal antibody titer is, the higher the incidence of HDN is and the higher the proportion of hemolysis is positive. The prenatal Ig G antibody titer of O-type pregnant women is positively correlated with the incidence of HDN.