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肿瘤耐药是当前肿瘤治疗的主要障碍。近年来,包括药物外排增强、药物亚细胞水平分布改变、药物亲和力改变、细胞解毒和修复功能加强及肿瘤细胞抗凋亡能力增强等肿瘤耐药相关生物学机制的研究已取得很大进展,这些生物学机制共同构建成一个复杂的网络系统,详尽阐明这一多因子的网络能够更好地预测肿瘤患者对治疗的应答及制定肿瘤患者的个体化治疗。应用蛋白质组学技术已在肿瘤细胞系和组织中鉴定出大量新的耐药相关性因子和蛋白表达标记物。本文就比较蛋白质组学研究方法在不同肿瘤细胞中所发现的耐药相关蛋白及机制进行综述与分析。
Tumor drug resistance is a major obstacle to the current cancer treatment. In recent years, great progress has been made in the study of the biological mechanisms of tumor resistance, including enhancement of drug excretion, changes of subcellular distribution of drugs, changes of drug affinity, enhancement of detoxification and repair of cells and enhancement of anti-apoptotic ability of tumor cells. Together, these biological mechanisms are engineered into a sophisticated web-based system that elaborates on this multifactorial network to better predict the response of cancer patients to treatment and to develop personalized therapies for cancer patients. Application of proteomics technology has identified a large number of new drug resistance-related factors and protein expression markers in tumor cell lines and tissues. This article reviews and analyzes the proteomic related proteins and mechanisms found in different tumor cells by comparing proteomic approaches.