【摘 要】
：
A novel myotoxic protein phospholipase A2 (PLA2), denoted as Gln49-PLA2, has been isolated from snake venom of Agkistrodon blomhoffii ussurensis, which has weak
【机 构】
：
Department of Bioscience and Biotechnology,Institute of Biophysics,Graduate School of Chinese Academ
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A novel myotoxic protein phospholipase A2 (PLA2), denoted as Gln49-PLA2, has been isolated from snake venom of Agkistrodon blomhoffii ussurensis, which has weak lethal effect and apparent anticoagulant activity, but lacks the PLA2 and hemorrhagenic activity. Gln49-PLA2 obviously increases of plasma creatine-kinase (CK) upon intramuscular injection in mice, suggesting that it may induce a dose-dependent myonecrosis. Histological studies also reveal morphological changes in mouse skeletal muscles, including extensive myonecrosis, hemorrhage and neutrophil infiltration in the treated animals. The myotoxic ability induced by Gln49-PLA2 can be partially inhibited by heparin.
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