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微小RNA-9(miR-9)家族是一类非编码小分子单链RNA,能通过参与基因转录后修饰调控基因的表达。近年来,癌症的发病率逐年升高,研究其机制和治疗方法具有十分重要的意义。许多类型的癌症都出现miR-9的表达量异常,提示miR-9可能与肿瘤的形成或发展有关。本文主要讨论miR-9在多种癌症和神经系统相关疾病中的研究现状,重点阐述miR-9在乳腺癌、胃癌、结肠癌、食管癌、人神经母细胞瘤和神经退行性疾病中的作用。
The microRNA-9 (miR-9) family is a class of small, non-coding single-stranded RNA that regulates gene expression by participating in post-transcriptional modifications. In recent years, the incidence of cancer increased year by year, to study the mechanism and treatment is of great significance. The abnormal expression of miR-9 in many types of cancers suggests that miR-9 may be involved in tumor formation or development. This review focuses on the current status of miR-9 in a variety of cancer and neurological related diseases and highlights the role of miR-9 in breast, gastric, colon, esophageal, human neuroblastoma, and neurodegenerative diseases .