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低密度脂蛋白( LDL)可以通过金属离子、酶、蛋白质糖基化和NO等多种途径发生氧化, 主要生成弱氧化低密度脂蛋白( mmLDL)和氧化低密度脂蛋白( oxLDL) . LDL 氧化产物可以通过多种成骨相关信号通路影响成骨分化.“,”Low-density lipoprotein ( LDL) can be oxidized via metal ions, enzymes, protein glycation and nitric oxide (NO) to produce minimally modified low-density lipoprotein (mmLDL) and oxidized low-density lipoprotein (oxLDL). LDL oxi-dation products can affect osteogenic differentiation through a variety of signaling pathways involved in osteogenesis.