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目的:分析炎症细胞因子在不同类型冠心病发生、发展过程中的作用并探讨其临床意义。方法:检测急性心肌梗死(AMI)组44例,不稳定型心绞痛(UAP)组44例,稳定型心绞痛(SAP)组43例及非冠心病患者(对照组)35例的血清白细胞介素(IL)-6、IL-8、IL-10和肿瘤坏死因子-α(TNF-α)浓度并进行比较。结果:与SAP组及对照组比较,AMI组和UAP组血清IL-6、IL-8、IL-10、TNF-α水平均明显升高(P<0.01);AMI组血清IL-10、TNF-α水平高于UAP组(P<0.05),组间血清IL-6、IL-8水平差异无统计学意义(P>0.05);SAP组和对照组之间比较,血清IL-6、IL-8、IL-10、TNF-α水平均差异无统计学意义(P>0.05)。结论:IL-6、IL-8、IL-10、TNF-α均参与了动脉粥样硬化斑块的形成和进展,血清细胞因子水平与冠心病病情严重程度密切相关。
Objective: To analyze the role of inflammatory cytokines in the occurrence and development of different types of coronary heart disease and to explore its clinical significance. Methods: 44 patients with acute myocardial infarction (AMI), 44 patients with unstable angina pectoris (UAP), 43 patients with stable angina pectoris (SAP) and 35 patients with non-coronary heart disease (control group) were enrolled in this study. Serum interleukin IL-6, IL-8, IL-10 and tumor necrosis factor-α (TNF-α) concentrations were compared and compared. Results: The levels of IL-6, IL-8, IL-10 and TNF-α in AMI group and UAP group were significantly higher than those in SAP group and control group (P <0.01) (P <0.05). There was no significant difference in serum IL-6 and IL-8 levels between the SAP group and the control group (P> 0.05) -8, IL-10, TNF-α levels were not significantly different (P> 0.05). Conclusion: IL-6, IL-8, IL-10 and TNF-α are involved in the formation and progression of atherosclerotic plaque. Serum levels of cytokines are closely related to the severity of coronary heart disease.