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目的:观察和分析异丙托溴铵和盐酸氨溴索雾化吸治疗慢性阻塞性肺部疾病急性加重期的临床疗效。方法:将115例慢性阻塞性肺部疾病急性加重期患者随机分为两组,对照组57例采取常规应用抗感染、平喘、吸氧、口服化痰药或静脉化痰药等进行治疗,治疗组58例在常规治疗的基础上加异丙托溴铵溶液500μg和盐酸氨溴索注射液15mg*2支联合雾化吸入,观察治疗前后与对照组在肺功能(FVE1%、FVE1/FVC)及动脉血气分析(PaO2、PaCO2)的改善情况。结果:治疗组总有效率为84.5%,对照组总有效率为77.2%,两组疗效有显著性差异(P<0.05)。结论:吸入用异丙托溴铵和盐酸氨溴索雾化吸入治疗慢性阻塞性肺部疾病急性加重期有良好的临床疗效,操作简单,值得推广。
OBJECTIVE: To observe and analyze the clinical efficacy of ipratropium bromide and ambroxol hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods: One hundred and fifteen patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into two groups. 57 patients in the control group were treated with anti-infection, asthma, oxygen inhalation, oral phlegm medicine or venous phlegm medicine, In the treatment group, 58 cases were treated with atomization inhalation of 500μg ipratropium bromide solution and 15mg * 2 ambroxol hydrochloride injection on the basis of conventional treatment. Before and after treatment, the pulmonary function (FVE1%, FVE1 / FVC ) And arterial blood gas analysis (PaO2, PaCO2) to improve the situation. Results: The total effective rate was 84.5% in the treatment group and 77.2% in the control group, with significant difference between the two groups (P <0.05). Conclusion: Inhalation with ipratropium bromide and ambroxol hydrochloride inhalation for the treatment of chronic obstructive pulmonary disease in acute exacerbation has a good clinical curative effect, which is easy to operate and worthy of promotion.