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缺氧诱导因子?1（ HIF?1）是细胞及组织在缺氧情况下产生的一种氧依赖的转录激活因子。研究发现在缺氧条件下，HIF?1与肿瘤干细胞的产生、干性的维持密切相关，并且调控多条干细胞相关的信号通路，促进肿瘤干细胞的侵袭、转移、上皮间质转化过程及血管生成，使肿瘤的耐药性增强和凋亡减少。由于HIF?1与肿瘤干细胞的发生发展关系密切，因此针对HIF?1的靶向治疗对于抑制和杀伤肿瘤干细胞具有重要的意义。“,”Hypoxia?inducible factor?1( HIF?1) is an oxygen?dependent transcriptional activator produced by cells and tissues under hypoxic conditions. Recent research indicates that HIF?1 is closely related with the generation and maintenance of cancer stem cells( CSCs) . Moreover, HIF?1 can regulate multiple signaling pathways related to CSCs, promote the invasion, metastasis, epithelial mesenchymal transition and angiogenesis of CSCs, enhance tumor resistance and reduce apoptosis under hypoxic conditions. Since HIF?1 is closed related with the generation and development of CSCs, the strategies targeting HIF?1 may play an important role for inhibiting and killing CSCs.