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Based on a systematic analysis about the design principles, systematic objectives, clients demands and functional modules of the regional karst desertification disaster information system, a systematic application plan was proposed in this paper that the mainstream technologies like COMGIS, etc. can be used for secondary development, and Duan Yao Autonomous County of Guangxi was taken as an example to illustrate the application of geographical information system in development of karst desertification disaster information system, and to provide a feasible plan for realization of accessory decision information aiming for sustainable development ofkarst desertification area.