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前列腺素(PGs)与生殖生理现象的关系日益受到重视,而孕卵着床及子宫内膜蜕膜化的关系尤为重要。由于分泌期子宫内膜抑制PGs合成,而蜕膜化的子宫内膜则产生PGs,这种PGs量的变化是否与妊娠早期绒毛所分泌的大量绒毛膜促性腺激素(hCG)有关,值得认真探讨。本文作者自妊娠6～8周妇女的子宫内取出蜕膜,迅速切成1～2 mm大小,称取约10mg放入有各种添加剂的培养液中,分别加入10IU,100IU和1,000IU的hCG,在9.5%O_2,5%CO_2,37℃下预孵育2小时,然后培养24小时,取出培养液中的PGs,用放免方法测定。结果表明,随着hCG量的增加,蜕膜中PGE_2,PGF_(2α),6-酮-PGF_(1α)的产生也增多。尤其是添加
The relationship between prostaglandin (PGs) and reproductive physiology has been paid more and more attention. The relationship between implantation and endometrial decidualization is very important. Because endometrial secretion during the inhibition of PGs synthesis, and decidualization of the endometrium PGs produced, the PGs volume changes and early pregnancy villus secreted large amounts of chorionic gonadotropin (hCG), should be carefully explored . The authors removed the decidua from 6 to 8 weeks gestation in women’s uterus and quickly cut into 1 ~ 2 mm size, weighed about 10mg into the medium with various additives, were added 10IU, 100IU and 1,000IU of hCG , Pre-incubated at 9.5% O 2, 5% CO 2, 37 ℃ for 2 hours and then cultured for 24 hours. The PGs in the culture medium were removed and determined by radioimmunoassay. The results showed that the production of PGE_2, PGF_ (2α) and 6-keto-PGF_ (1α) also increased in decidua with the increase of hCG content. Especially add