耐新青霉素Ⅰ菌株及其他的多重耐药金黄色葡萄球菌引起的感染现在越来越多见,而且,即使是对抗生素敏感的菌株所引起严重的金黄色葡萄球菌感染,治疗上也十分困难。抗生素的联合应用有助于解决以上两个问题,对此也已有一定的体外研究。然而如何将体外实验结果用以解释临床现象的问题至今仍未得到解决。本研究目的在于评价在体外和小鼠感染模型实验中抗生素联合应用的结果。研究了洁霉素(clindamycin)和利福平,以及邻氯青 Infection with new penicillin-resistant strains and other multidrug-resistant Staphylococcus aureus is now more and more common, and even antibiotic susceptible strains cause severe infections of Staphylococcus aureus and are difficult to treat. The combined use of antibiotics will help to solve the above two problems, which also have some in vitro studies. However, the question of how to use in vitro experimental results to explain clinical phenomena has not been solved yet. The purpose of this study was to evaluate the combined use of antibiotics in in vitro and in mouse model of infection. Studied clindamycin and rifampin, as well as o-chlorocyanine