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目的:对比观察宣肺化痰方标准煎剂及煮散剂的药理作用。方法:大鼠分为8组,分别灌入等体积蒸馏水、急支糖浆、宣肺化痰方标准煎剂高、中、低剂量(含生药46.80,23.40,11.70 g.kg-1)、宣肺化痰方煮散剂高、中、低剂量(含生药23.40,11.70,5.85 g.kg-1),观察对小鼠毛细血管通透性的影响、对氨水致小鼠咳嗽的影响、对磷酸组胺诱发豚鼠哮喘的影响、对小鼠气管酚红排泌的影响、对慢性支气管炎大鼠超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。结果:宣肺化痰方标准煎剂和煮散剂均能显著降低小鼠毛细血管通透性;延长小鼠咳嗽潜伏期和减少咳嗽次数;延长豚鼠引喘潜伏期;增加小鼠气管酚红排泌量;升高慢性支气管炎大鼠血清SOD活性,降低MDA含量。宣肺化痰方标准煎剂和煮散剂比较,两者在同剂量组级别(高、中、低)之间作用无显著性差异。结论:宣肺化痰方标准煎剂和煮散剂均有显著抗炎、止咳、平喘和化痰作用,两者作用无显著性差异。
OBJECTIVE: To compare the pharmacological effects of standard decoction of Xuanfei Huatan prescription and boiled powder. Methods: The rats were divided into 8 groups, respectively, with equal volume of distilled water, acute bronchitis syrup, Xuanfei Huatan decoction standard decoction of high, medium and low doses (including crude drugs 46.80,23.40,11.70 g.kg-1), declared Pulmonary phlegm boiled powder high, medium and low doses (including crude drugs 23.40,11.70,5.85 g.kg-1), observed the permeability of mice capillary permeability, the impact of ammonia-induced mouse cough, phosphate Effects of histamine on the asthma in guinea pigs, the effects of tracheal phenol red excretion in mice and the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in rats with chronic bronchitis. Results: Xuanfei Huatan Fang decoction and boiled powder can significantly reduce capillary permeability in mice; extend mouse cough latency and reduce the number of coughs; prolong the incubation period of guinea pig induced by asthma; increase mouse tracheal phenol red excretion ; Increase serum SOD activity and reduce the content of MDA in chronic bronchitis rats. Xuanfei Huatan standard decoction and boiled powder compared with the same dose group level (high, medium and low) no significant difference between the role. Conclusion: The standard decoction of Xuanfei Huatan decoction and boiled powder have significant anti-inflammatory, anti-cough, antiasthmatic and phlegm-reducing effect. There is no significant difference between the two.