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目的探讨二甲双胍对PCOS合并胰岛素抵抗患者的临床症状及内分泌、代谢指标的影响。方法胰岛素抵抗患者33例,予二甲双胍治疗3个月,观察治疗前后临床症状及内分泌、代谢指标的改善情况。结果二甲双胍治疗后胰岛素抵抗患者BMI降低,多毛、痤疮有不同程度的减轻。FSH升高(P<0.05),LH、FINS、HOMA-IR、LDL-C、hsCRP及IL-6均明显降低(P<0.01),而HDL-C明显升高(P<0.01)。结论二甲双胍可明显改善伴胰岛素抵抗的PCOS患者的临床症状和内分泌、代谢指标,可预防代谢综合征。
Objective To investigate the effects of metformin on clinical symptoms, endocrine and metabolic indices in PCOS patients with insulin resistance. Methods Thirty-three patients with insulin resistance were treated with metformin for 3 months. The clinical symptoms, endocrine and metabolic parameters were observed before and after treatment. Results After treatment with metformin, patients with insulin resistance decreased BMI, hirsutism and acne to varying degrees. FSH increased (P <0.05), LH, FINS, HOMA-IR, LDL-C, hsCRP and IL-6 decreased significantly while HDL-C increased significantly (P <0.01). Conclusion Metformin can significantly improve the clinical symptoms and endocrine and metabolic indices of PCOS patients with insulin resistance and prevent metabolic syndrome.