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目的:制备汉黄芩素固体脂质纳米粒并对其体外释放度进行考察。方法:采用乳化分散-超声法制备汉黄芩素固体脂质纳米粒,以包封率和载药量为评价指标,进行正交试验筛选最优处方,并对最优处方的外观、粒径和体外释放度进行考察。结果:制得的纳米粒为均一球形,平均粒径为(153±34)mm,其平均载药量为(60.53±2.17)%,平均包封率为(85.54±4.16)%,48 h累积释放达80%。结论:本试验获得了较理想的汉黄芩素固体脂质纳米粒,其体外释放具有缓释作用。
Objective: To prepare wogonin solid lipid nanoparticles and investigate its in vitro release. Methods: Wackerberry solid lipid nanoparticles were prepared by emulsification-dispersion-ultrasound method. The entrapment efficiency and drug loading were used as evaluation indexes. The optimal prescription was screened by orthogonal test. The appearance, particle size, In vitro release was investigated. Results: The average diameter of the prepared nanoparticles was (153 ± 34) mm, the average drug loading was (60.53 ± 2.17)% and the average encapsulation efficiency was (85.54 ± 4.16)% Release up to 80%. Conclusion: This study obtained the ideal wogonin solid lipid nanoparticles, in vitro release with sustained-release effect.