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【目的】探讨晚期结直肠癌患者化疗后血清基质金属蛋白酶-7(MMP-7)水平变化与化疗疗效的关系。【方法】采用 ELISA 法检测61例晚期结直肠癌患者(化疗组)、52例健康体检者(对照组)血清 MMP-7水平，比较晚期结直肠癌患者化疗前后血清 MMP-7水平变化，按照 WHO 标准评估近期疗效。【结果】晚期结直肠癌患者血清MMP-7水平明显高于正常对照组，差异有统计学意义(P <0.05)；化疗后，晚期结直肠癌患者血清 MMP-7水平明显下降，差异有统计学意义(P <0.05)；有效组血清 MMP-7水平比化疗前明显降低(P 0.05)；有效组化疗后血清 MMP-7水平明显低于无效组(P <0.05)。【结论】晚期结直肠癌血清 MMP-7水平降低与化疗疗效有关，化疗后血清 MMP-7水平明显降低提示疗效较好，其血清水平的检测可能有助于评价化疗近期疗效。“,”Objective]To study the relationship between serum matrix metalloprotein-ase-7 levels and the efficacy of chemotherapy in patients with advanced colorectal cancer.[Methods]Serum MMP-7 were detected with enzyme linked im-munosorbent assay (ELISA)in 61 cases of patients with advanced colorectal cancer (chemotherapy group)and 52 cases of normal control subjects.The Serum MMP-7 levels were also compared before and after chemotherapy in 61 advanced colo-rectal cancer Patients.The therapeutic efficacy was evaluated according to WHO standards.[Results]The MMP-7 level was significantly higher in patients with advanced colorectal colorectal cancer group than the control group and the differ-ence was statistically significant (P <0.05).After chemotherapy,serum MMP-7 level was significantly decreased,and the difference was statistically significant (P <0.05).The serum level of MMP-7 was significantly dropped (P 0.05).The serum MMP-7 level was significantly lower in the therapeutic-effective group than the therapeutic-ineffective group (P <0.05).[Conclusion]The changes of MMP-7 level in patients with advanced colorectal cancer are related to chemothera-peutic efficacy.A markedly decreased MMP-7 level after chemotherapy indicates a better therapeutic efficacy.The detec-tion of serum MMP-7 level may help evaluate the term effect of chemotherapy.