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糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetes mellitus,DM)最主要的微血管并发症之一,也是导致慢性肾功能衰竭的主要原因之一。如何阻止DN的发展是当今临床医学的重要难题。DN早期的病理特征是肾小球、肾小管细胞肥大伴基底膜增厚,临床表现为高滤过和微量蛋白尿[1]。糖尿病肾病进展导致肾小球系膜基质增加,促进肾小球硬化和肾小球间质纤维化,使肾小球功能丧失
Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes mellitus (DM), which is also one of the main causes of chronic renal failure. How to prevent the development of DN is an important problem in clinical medicine today. DN early pathological features of glomerular tubular cell hypertrophy with basement membrane thickening, clinical manifestations of hyperfiltration and microalbuminuria [1]. Progress in diabetic nephropathy leads to increased glomerular mesangial matrix, promoting glomerular sclerosis and glomerular interstitial fibrosis, glomerular dysfunction