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作者应用胃癌单克隆抗体MG7对289例胃粘膜活检标本进行PAP免疫组织化学观察,发现伴有肠化生的萎缩性胃炎组(20.0％)与伴有肠化生的癌旁粘膜组(62.1％)间、弥漫型胃癌癌旁粘膜肠化生组(41.7％)与肠型胃癌癌旁粘膜肠化生组(76.5％)间、轻型不典型增生组(23.9％)与中重度不典型增生组(54.0％)间,MG7-Ag表达阳性率均有显著性差异(均为P<0.01)。在胃癌组织中MG7-Ag表达阳性率为87.8％,而8例正常胃粘膜均阴性。结果表明,胃癌单克隆抗体MG7对胃癌的诊断具有较高的特异性;肠化生与胃癌(尤其是肠型胃癌)的发生有密切关系;对MG7-Ag表达阳性的肠化生和异型增生患者加强随访,将有利于胃癌的早期发现。
The authors applied gastric cancer monoclonal antibody MG7 to 289 gastric mucosa biopsy specimens for PAP immunohistochemical observation and found atrophic gastritis with intestinal metaplasia (20.0%) and paracancer mucosa with intestinal metaplasia (62.1%). Interstitial mucosal metastasis of interstitial gastric cancer (41.7%) and intestinal metastatic gastric carcinoma (46.5%), mild dysplasia (23.9%) and moderate to severe dysplasia (54.0%), there was a significant difference in the positive rate of MG7-Ag expression (all P<0.01). The positive rate of MG7-Ag expression in gastric cancer was 87.8%, and 8 cases of normal gastric mucosa were negative. The results showed that the gastric cancer monoclonal antibody MG7 has high specificity for the diagnosis of gastric cancer; intestinal metaplasia is closely related to the occurrence of gastric cancer (especially bowel type gastric cancer); and intestinal metaplasia and dysplasia are positive for MG7-Ag expression. Strengthening follow-up of patients will facilitate the early detection of gastric cancer.