长期以来,人们对生物信号蛋白的研究一直停留在对其信号通路,即信号蛋白与其上下游因子构成的网络结构这一层面。信号蛋白动力学的出现标志着人类对信号分子的认识达到了一个新的层次,使得人们对信号网络的认知实现从“静态”到“动态”的飞跃。作为重要的细胞命运决策者,P53蛋白的动力学行为是近年来分子生物学及系统生物学领域研究的热点。本文综述了P53蛋白动力学行为的最新研究成果,分析了构成P53动力学行为的分子结构基础及其对应的生物学功能,提出了P53蛋白动力学的深入研究方向。 For a long time, people’s study of biological signal proteins has been at the level of its signaling pathway, that is, the network structure of signal proteins and their upstream and downstream factors. The emergence of signal protein dynamics marks a new level of human cognition of signal molecules, which makes people realize the leap of signal network from “static ” to “dynamic ”. As an important decision maker of cell fate, the kinetics of P53 protein has been a hot topic in molecular biology and system biology in recent years. This review summarizes the latest research results on the kinetics of P53 protein, analyzes the molecular structure basis and its corresponding biological function of P53 dynamic behavior, and puts forward the further research direction of P53 protein kinetics.