奥美拉唑(Omeprazole,OME)。随着临床使用的日趋广泛,不良反应也随之增多,本文就此作一浅述。 1 OME的作用特点与最佳服用时间 目前临床使用OME抗消化性溃疡,多采用20mg/d,qd。那么1天24h之内何时服用效果最佳?由于人体分泌胃酸夜间比白天多,胃酸分泌越多,对胃粘膜损害就越强烈,对OME的吸收也越有利,并使药物迅速沉积在壁细胞内,通过抑制壁细胞H~+—K~+—ATP酶(质子泵),从而阻断胃酸分泌终端步骤,产生强力的剂量依赖性抑制胃酸分泌作用。 Omeprazole (OME). With the wide range of clinical use, adverse reactions also will increase, this article makes a brief account. 1 OME’s role and the best time to take the current clinical use of OME anti-peptic ulcer, and more use of 20mg / d, qd. Then within 1 day 24h when to take the best effect? ​​As the body secretes more acid during night than during the day, the more gastric acid secretion, the more intense damage to the gastric mucosa, the more favorable absorption of OME, and the rapid deposition of drugs in the wall Intracellular, by blocking parietal cells H ~ + -K ~ + -ATPase (proton pump), thereby blocking the gastric acid secretion terminal steps, resulting in a strong dose-dependent inhibition of gastric acid secretion.