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目的探讨甲状腺功能异常与脑出血急性期出血量的相关性。方法将220例脑出血急性期患者根据患者有无甲状腺功能异常分为试验组(甲状腺功能异常组)和对照组(甲状腺功能正常组)各110例。要求所有患者接受控制血压、维持呼吸道通畅、保护脑细胞、脱水降颅压以及维持电解质平衡等针对急性脑出血的常规治疗。常规化验2组患者的血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离T3(FT3)、游离T4(FT4)、促甲状腺激素(TSH)水平,比较2组患者出血及预后情况。结果脑出血急性期试验组患者血清T3、FT3水平明显低于对照组,血清T4、FT4、TSH明显高于对照组,差异均有统计学意义(P<0.05)。试验组中大量出血者明显多于对照组,而小量出血者明显少于对照组(P均<0.05)。试验组患者平均出血量显著高于对照组,病死率高于对照组,痊愈率显著低于对照组(P均<0.05)。此外,试验组中甲状腺功能轻度异常者和重度异常者除在小量出血一项上无明显差异外,其余各项差异明显(P<0.05)。结论甲状腺功能异常与脑出血患者的病情程度明显相关,重度异常患者出血量多,病死率高。
Objective To investigate the correlation between thyroid dysfunction and the amount of hemorrhage in acute stage of cerebral hemorrhage. Methods A total of 220 patients with acute cerebral hemorrhage were divided into experimental group (thyroid dysfunction group) and control group (thyroid function normal group) according to whether the patients had thyroid dysfunction or not. All patients were required to receive routine treatment for acute intracerebral hemorrhage such as controlling blood pressure, maintaining airway patency, protecting brain cells, dehydration and intracranial pressure, and maintaining electrolyte balance. The levels of serum T3, T4, FT3, FT4 and TSH in the two groups were compared. The bleeding and prognosis of the two groups were compared Happening. Results Serum levels of T3 and FT3 in the acute phase of cerebral hemorrhage were significantly lower than those in the control group. The levels of T4, FT4 and TSH in the experimental group were significantly higher than those in the control group (P <0.05). A large number of bleeding in the experimental group was significantly more than the control group, while a small amount of bleeding was significantly less than the control group (P all <0.05). The mean bleeding volume of the experimental group was significantly higher than that of the control group, the mortality was higher than the control group, the cure rate was significantly lower than the control group (P all <0.05). In addition, the test group mild hypothyroidism and severe abnormalities in addition to a small amount of bleeding was no significant difference, the rest of the difference was significant (P <0.05). Conclusions Thyroid dysfunction is significantly associated with the severity of cerebral hemorrhage in patients with severe abnormalities, more bleeding and high mortality.