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目的了解学龄前儿童pH1N1、H3N2和Bv流感抗体水平,为制定儿童流感防控措施提供依据。方法随机采集广州市某三甲医院204名学龄前儿童血清,利用血凝抑制方法(HI assay)检测儿童pH1N1、H3N2和Bv型流感抗体;采用SPSS19.0软件分析3个亚型/型别流感抗体阳性率、抗体几何平均滴度(GMT)和无免疫率(No-immunity ratio)。结果学龄前儿童pH1N1、H3N2和Bv毒株的总体抗体阳性率分别为41.7%、80.4%和36.3%,无免疫率分别为40.2%、4.9%和31.4%;其中H3N2抗体阳性率最高;pH1N1无免疫率最高。>2岁年龄组的3种流感抗体阳性率均最高,>2岁年龄组与02岁年龄组之间的3种抗体水平差异有统计学意义;患有基础疾病儿童3种抗体水平均较一般儿童略高。结论学龄前儿童对于pH1N1及Bv流感毒株易感性较高,对H3N2毒株多有特异性免疫抗体;6月~2岁儿童以及有基础疾病的儿童为pH1N1型流感的重点防控人群。
Objective To understand the level of antibodies against pH1N1, H3N2 and Bv in preschool children and provide evidence for the development of influenza prevention and control measures in children. Methods Serum of 204 preschool children in a top-three hospital in Guangzhou were collected at random. The HI antibody was used to detect the antibody against pH1N1, H3N2 and Bv in children. The three subtype / type influenza antibodies were analyzed by SPSS19.0 software Positive rate, geometric mean antibody titer (GMT) and no-immunity ratio (No-immunity ratio). Results The positive rates of total antibodies against pH1N1, H3N2 and Bv strains in pre-school children were 41.7%, 80.4% and 36.3%, respectively, with no immunization rates of 40.2%, 4.9% and 31.4%, respectively. Among them, the positive rate of H3N2 antibody was the highest; The highest immunization rate. > 2 years old group had the highest positive rate of the three kinds of influenza antibodies, and there was a significant difference in the levels of the three antibodies between> 2-year-old group and 02-year-old group. The levels of 3 kinds of antibodies in children with underlying diseases were generally higher Children slightly higher. Conclusions Preschoolers are more susceptible to pH1N1 and Bv influenza strains and have more specific antibodies against H3N2 strains. Children aged 6 months to 2 years old and children with underlying diseases are the key prevention and control people of pH1N1 influenza.