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目的：探讨跨声门癌与声门上癌的差异。方法：５０例跨声门癌及１００例声门上癌喉全切除标本，ＨＥ染色，光镜观察。结果：跨声门癌主体位于喉室或以喉室为中心向声门上区、声门区以基本均等态式浸润扩展。粘膜下深层浸润方式占５２％（２６／５０）。声门旁间隙受累为８２％（４１／５０），呈以喉室为中心的对称性浸润。甲状软骨受累率为５２％（２６／５０）；声门上癌主体位于喉室以上的声门上区。粘膜下深层浸润方式占９％（９／１００）。声门旁间隙受累为４８％（４８／１００），呈非对称性浸润。会厌软骨受累２８％（２８／１００）。结论：跨声门癌在临床、病理等诸多方面不同于声门上癌，应列为独立型的跨声门喉癌。
Objective: To explore the differences between transglottic cancer and supraglottic cancer. Methods: A total of 50 cases of transglottic carcinoma and 100 cases of supraglottic carcinoma were treated with total hepatectomy and HE staining. RESULTS: The transglottic cancer was located in the larynx or central area of the glottis with the larynx as the center. Submucosal deep infiltration accounts for 52% (26/50). Peri-glottic space involvement was 82% (41/50), with symmetrical infiltration of the larynx. The incidence of thyroid cartilage was 52% (26/50); the supraglottic cancer was located in the supraglottic area above the larynx. Submucosal deep infiltration accounts for 9% (9/100). The paraglottic space involved 48% (48/100) of asymmetrical infiltration. Epiglottis cartilage involved 28% (28/100). Conclusion: Transglottic cancer is different from supraglottic cancer in many aspects such as clinical and pathological, and should be classified as an independent transglottic carcinoma.