【摘 要】
：
The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former surveillance data.In order to explore the potential
【机 构】
：
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental H
论文部分内容阅读
The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former surveillance data.In order to explore the potential genotoxicants contributing to the double-endpoint genotoxicity of polluted drinking water source,12 groundwater and 3 surface water samples were collected from 3 villages and the nearby rivers alongside Yinghe river basin,respectively and their comprehensive genotoxicity was estimated with a bioassay group of SOS/umu test and micronucleus (MN) test (MNT).Some groundwater samples showed positive genotoxicity and all surface water samples were highly genotoxic.Eight groundwater samples showed DNA genotoxic effect with the average 4-NQO equivalent concentration (TEQ(4-NQO)) of 0.067 μg/L and 0.089 μg/L in wet and dry season,respectively.The average MN ratios of groundwater samples were 14.19‰ and 17.52‰ in wet and dry season,respectively.Groundwater samples showed different genotoxic effect among 3 villages.The total PAHs concentrations in all water samples ranged from 8.98 to 25.17 ng/L with an average of 14.97±4.85 ng/L.BaA,CHR,BkF,BaP and DBA were the main carcinogenic PAHs contributing to the genotoxicity of water samples.In conclusion,carcinogenic PAHs are possibly related to the high tumor mortality in the target area.Characterization of carcinogenic PAHs to genotoxicity of drinking water source may shed light on the etiology study for high tumor mortality in Yinghe river basin.
其他文献
盐皮质激素受体(MR)通过调节肾脏对钠和钾的重吸收参与维持体内离子平衡.大量研究表明盐皮质激素受体拮抗剂(MRA)可通过抑制MR激活引起的炎症和纤维化达到延缓慢性肾脏病(CKD)进展的作用,且该效应与其降压作用部分独立.本文将从不同方面介绍MRA在CKD治疗中的研究进展,为临床应用提供参考.
人工智能技术是近年来发展迅速的一门新兴学科,目前广泛应用于医学多个领域.肾脏病理是肾脏疾病诊断的金标准,已有多项研究显示人工智能技术能够在肾脏病理中得到很好的应用,包括肾小球、肾小管、间质和动脉等基本结构和病变的识别,预测肾脏病理分型(级)和患者预后等,从而实现自动化肾脏病理特征定量、病理分型(级)及预后判断.本文就目前人工智能技术在肾脏病理中的研究进展作一综述.
常染色体显性遗传性多囊肾病(autosomal dominant polycystic kidney disease,ADPKD)发生代谢重编程,有氧糖酵解明显上调,为囊肿衬里上皮细胞的增殖提供充足的能量及生产底物.多囊蛋白能通过直接和间接的方式调节线粒体功能,功能蛋白的丢失使线粒体形态、功能发生改变,存在明显的氧化应激.本文对ADPKD的能量代谢改变特征、线粒体功能障碍的特征及发生机制进行综述和讨论,并总结干预ADPKD能量代谢的潜在临床靶点.
载脂蛋白E(apoE)在脂蛋白代谢中起关键作用,其突变可引起apoE结构功能障碍,介导apoE相关肾小球疾病,如apoE2纯合子肾小球病和脂蛋白肾病(LPG)等.apoE2纯合子肾小球病组织学特征为肾小球硬化,可见来自巨噬细胞的泡沫细胞浸润,偶有非层状脂蛋白栓子形成.巨噬细胞不仅参与泡沫细胞的形成,其功能障碍也可导致脂蛋白在肾小球积聚,引起脂蛋白栓子.携带apoE Toyonaka(Ser197Cys)突变纯合子apoE 2/2基因型的患者,肾小球可以出现非免疫性膜性肾病样特征.LPG可见不伴泡沫细胞的片
在临床数据的统计分析中,我们常会遇到数据缺失.根据数据的缺失情况,使用妥当的方法处理缺失值关系着统计推断的可靠性和准确性.本文对数据缺失的模式、比例和常见的处理方法进行了简单的总结,对基于R语言程序包mice的多重填补的流程和内容进行了详细的梳理,并以急性肾损伤的影响因素分析为例,展示和对比基于多重填补数据集、缺失数据集和原始数据集的广义线性模型的结果.结果表明,多重填补可以很好地对定量变量、二分类变量和有序多分类变量进行填补,基于多重填补数据集的模型结果稳健、可靠.
急性肾损伤(AKI)是严重创伤的常见并发症,绝大多数的AKI发生在创伤发生时或创伤后数天内.AKI与创伤患者住院时间延长和死亡率增加独立相关,其发病机制包括失血性休克、创伤性炎症、横纹肌溶解、腹腔内高压、直接肾损伤等.本文就创伤相关AKI的最新进展作一综述.
系统性红斑狼疮(SLE)是一种累及多系统的自身免疫性疾病,肠道受累并非罕见,并且狼疮性肾炎患者合并肠道受累比例增高.由于SLE相关肠道损伤表现多样且无特异性,临床上容易误诊漏诊,如不及时有效治疗甚至威胁生命.早期识别可改善预后,降低死亡率.本文综述常见的SLE相关肠道损伤,包括狼疮性肠炎、假性肠梗阻和蛋白丢失性肠病的诊治进展.
45岁男性患者,因“同种异体肾移植术后3年余,发热10d”入院,临床表现为发热伴寒战、少许咳嗽,胸部CT表现为右下肺结节伴空洞形成.血标本送二代测序检测,结果提示马尔尼菲篮状菌,予两性霉素B静滴和伏立康唑口服续惯治疗,随访6个月,完全好转.
高血压与肾脏病互为因果,慢性肾脏病(CKD)患者血压控制标准较普通人群要求更严格,达标更困难,新型降压药物血管紧张素受体-脑啡肽酶抑制剂(ARNI)的出现为肾性高血压的降压治疗提供了新的方案.目前研究表明,ARNI的降压疗效较传统五大类降压药物强,且能为心、肾等靶器官提供更好的保护;在安全性方面,也优于单一的肾素-血管紧张素-醛固酮系统(RAAS)抑制剂.ARNI在CKD患者中的临床应用值得进一步探索.
The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data including infectious diarrhea cases among c