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目的:探讨癌舒康胶囊治疗癌症恶病质的作用机理。方法:建立T739小鼠癌症恶病质模型,观察癌舒康胶囊对恶病质小鼠的一般状况,如体重、摄食量、饮水量的影响;是否延长生存时间及提高生命延长率,观察血清中TNFa及血脂的水平变化。结果:癌舒康胶囊能明显增加癌症恶病质小鼠体重、摄食量及饮水量(P<0.01),延长生存时间,提高生命延长率(P<0.05);可显著抑制血清中甘油三酯(TG)和胆固醇(Ch)的异常升高(P<0.01);显著降低血清细胞因子TNFa水平(P<0.01)。结论:中药癌舒康胶囊对小鼠的癌症恶病质有较好的治疗作用,其作用机理与其调节TNFa及抑制脂肪分解等有关。
Objective: To investigate the mechanism of cancer Shuxue capsule treatment of cancer cachexia. METHODS: A T739 mouse cancer cachexia model was established to observe the effects of the cancer Shukang capsule on general conditions of mice with cachexia, such as the effects of body weight, food intake, and water intake; whether to prolong survival time and increase life extension rate; to observe TNFa and serum lipids in serum. The level of change. RESULTS: The Infantile Capsules can significantly increase body weight, food intake, and water intake in mice with cancer cachexia (P<0.01), prolong survival time, and increase survival rate (P<0.05); and significantly inhibit serum triglyceride (TG). ) and cholesterol (Ch) abnormal increase (P <0.01); significantly reduced serum cytokine TNFa levels (P <0.01). Conclusion: The traditional Chinese medicine Shanshukang capsule has a good therapeutic effect on cancer cachexia in mice, and its mechanism of action is related to its regulation of TNFa and inhibition of lipolysis.