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目的:探讨血液灌流(HP)治疗强度对急性百草枯中毒(APQP)的预后和死亡率的影响。方法:将2010年3月至2013年10月收治的APQP患者63例按照治疗方法分为对照组31例和研究组32例,两组均予综合治疗,对照组患者在洗胃后即给予1次HP治疗,研究组3次HP治疗,每次间隔6 h。比较两组在HP前(T1)及HP后即刻(T2)、10 h(T3)、20 h(T4)的血清百草枯(PQ)水平和死亡率。结果 :两组在T2、T3、T4时间点的血清PQ水平虽均明显低于T1(P<0.05),但研究组在T2、T3、T4时间点的血清PQ水平均明显低于对照组(P<0.05);研究组死亡率虽低于对照组,但无显著性差异(P>0.05)。结论 :虽然多次HP不能显著降低APQP的死亡率,但在常规对症、支持的基础上尽早、尽快、多次进行HP治疗可提高PQ的清除,改善预后。
Objective: To investigate the effect of hemoperfusion (HP) treatment on the prognosis and mortality of acute paraquat poisoning (APQP). Methods: 63 cases of APQP patients who were treated from March 2010 to October 2013 were divided into control group (31 cases) and study group (32 cases). Both groups were given comprehensive treatment. Patients in the control group were given 1 HP treatment, the study group 3 HP treatment, each interval of 6 h. The levels of paraquat (PQ) and mortality in the two groups before (T1) and immediately after HP (T2), 10 h (T3), 20 h (T4) Results: Serum PQ levels at T2, T3 and T4 were significantly lower than those at T1 (P <0.05), but serum PQ levels at T2, T3 and T4 in study group were significantly lower than those in control group P <0.05). Although the death rate of the study group was lower than that of the control group, there was no significant difference (P> 0.05). Conclusion: Although many times of HP can not significantly reduce the APQP mortality, but on the basis of conventional symptomatic and supportive as soon as possible, multiple HP treatment can improve the clearance of PQ and improve the prognosis.