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目的:探讨血清前白蛋白检测在肺结核病用药后肝损害早期诊断价值。方法:分别对90例门诊健康体者和85例确诊为肺结核的病人服药前后血清前白蛋白(PA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)进行检测。结果:肺结核病人在抗结核药物治疗前与健康对照组血清PA检测结果比较无显著性差异(P>0.05),治疗后血清PA水平结果降低(P<0.05)。在早期(2周)抗结核治疗中PA的异常率为84.7%,明显高于ALT、AST异常率的25.8%和31.8%。结论:将血清前白蛋白作为肺结核病人服药前后肝功能检测常规能及时发现肝脏的早期损害,比ALT、AST更灵敏。
Objective: To investigate the value of serum prealbumin in the early diagnosis of liver damage after pulmonary tuberculosis treatment. Methods: Serum prealbumin (PA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in 90 outpatients and 85 patients diagnosed with pulmonary tuberculosis. Results: There was no significant difference in the serum PA levels between TB patients and healthy controls before treatment (P> 0.05). The serum PA level decreased after treatment (P <0.05). In the early (2 weeks) anti-TB treatment, the abnormal rate of PA was 84.7%, which was significantly higher than that of ALT and AST (25.8% and 31.8%). Conclusion: Pretreatment of serum albumin as tuberculosis patients before and after taking the routine liver function tests can detect liver damage in time, more sensitive than ALT, AST.