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目的本研究探讨重度化学性眼烧伤后行羊膜移植术对重建眼表的临床疗效。方法采集2005年9月至2009年9月入院的重度化学性眼烧伤(Ⅲ～IV度)患眼31例41只眼,分为手术组和对照组。手术组19例26只眼(Ⅲ度16只眼,IV度10只眼),行羊膜移植术(anmiotic membrane transplantation,AMT),对照组12例15只眼(Ⅲ度9只眼,IV度6只眼)予常规治疗。术后随访12个月,观察角结膜上皮修复情况、羊膜的情况、术眼视力及并发症等。结果 1.手术组AMT全部成功,角膜修复时间5～15周,角膜修复率为88.5%;对照组角膜修复时间7～19周,角膜修复率为60.0%。2.手术组的脱盲率好于对照组,发生并发症的情况少于对照组,比较差异均有统计学意义(P<0.05)。结论羊膜移植手术可以迅速恢复烧伤眼表的完整性,促进角膜修复、维护眼表稳定。
Objective This study was to investigate the clinical effect of amniotic membrane transplantation for reconstruction of ocular surface after severe chemical eye burns. Methods A total of 41 eyes (31 eyes) with severe chemical eye burns (Ⅲ ~ Ⅳ degrees) hospitalized from September 2005 to September 2009 were divided into operation group and control group. The operation group consisted of 26 eyes (16 eyes of Ⅲ degree and 16 eyes of degree Ⅲ, 10 eyes of IV degree) underwent an amniotic membrane transplantation (AMT) and 12 eyes of 15 eyes (Ⅲ degree, 9 eyes, IV degree 6 Eye) to conventional treatment. The patients were followed up for 12 months. The keratoconjunctival epithelial repair, amniotic membrane, visual acuity and complications were observed. The results showed that the corneal repair rate was 60.5% and the corneal repair rate was 88.5%. The corneal repair rate was 60.0% in the control group between 7 and 19 weeks. 2. The operation group’s literacy rate is better than that of the control group, the incidence of complications is less than the control group, the difference was statistically significant (P <0.05). Conclusion Amniotic membrane transplantation can quickly restore the integrity of burn ocular surface, promote corneal repair, and maintain eye stability.