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目的 探讨几种常用肿瘤标记物CEA、NSE、LTA检测与影像学诊断对肺癌的检查及病理分型相关研究。资料与方法 选择 190例肺部病变的患者 ,均摄胸部X线平片和CT扫描及肿瘤标记物CEA、NSE、LTA外周血清检测。结果 (1)CT诊断鳞癌 5 0例、腺癌 4 6例、小细胞性未分化癌 14例、良性病变 2 0例、未定型 6 0例。 (2 )三项肿瘤标记物检测水平及敏感性鳞癌LTA为 85 .3% ,腺癌CEA为 86 .9% ,小细胞未分化癌NSE为 93.3%。 (3)影像学诊断与肿瘤标记物相结合 ,定性诊断及病理分型上升率鳞癌为 14 .7% ,腺癌 11.5 % ,小细胞未分化癌为 4 6 .7%。结论 影像学检查与几种常见肿瘤标记物检测结合在肺癌的诊断、病理分型及良恶性病变的鉴别起着重要的作用 ,为临床诊断及治疗提供更可靠的依据
Objective To investigate the correlation between CEA, NSE, LTA and imaging diagnosis of lung cancer and pathological classification of several commonly used tumor markers. Materials and Methods Totally 190 patients with pulmonary lesion were examined by X - ray, CT scan and tumor markers CEA, NSE and LTA. Results (1) CT was diagnosed in 50 cases of squamous cell carcinoma, 46 cases of adenocarcinoma, 14 cases of small cell undifferentiated carcinoma, 20 cases of benign lesions and 60 cases of unconfined ones. (2) The detection level and sensitivity of three tumor markers were 85.3% in squamous cell carcinoma, 86.9% in adenocarcinoma and 93.3% in small cell undifferentiated carcinoma. (3) The combination of imaging diagnosis and tumor markers, qualitative diagnosis and pathological classification of the rate of increase of squamous cell carcinoma was 14.7%, adenocarcinoma 11.5%, small cell undifferentiated carcinoma was 46.7%. Conclusion Radiographic examination combined with detection of several common tumor markers plays an important role in the diagnosis of lung cancer, pathological classification and differential diagnosis of benign and malignant lesions, providing a more reliable basis for clinical diagnosis and treatment