论文部分内容阅读
目的探讨注射用七叶皂苷钠治疗包皮环切术后水肿的疗效观察。方法拟行包皮环切术患者150例,随机分成治疗组和对照组,各75例。对照组术后在常规换药、抗感染治疗的基础上口服迈之灵片,0.15 g口服,b.i.d.,早晚各1次,7 d为1个疗程。治疗组术后给予常规换药、抗感染治疗,同时治疗组术前1 d开始使用注射用七叶皂苷钠20 mg加入10%葡萄糖注射液250 ml,静脉滴注,q.d.,7d为1个疗程。两组术后均未使用其他抗炎、脱水药物。术后随访观察2周,记录水肿发生情况及消退时间。评估两组患者水肿消退时间,术后7 d轻度、中度、重度水肿情况,伤口愈合以及总有效率比较。结果治疗组水肿消退时间明显较对照组短(P<0.01);治疗组水肿严重程度较对照组明显减轻(P<0.01);切口愈合情况明显优于对照组(P<0.01);治疗组总有效率为96%,对照组总有效率为72%,两组之间比较差异有统计学意义(P<0.01)。结论注射用七叶皂苷钠治疗包皮环切术后水肿,快速抑制渗出,消除包皮水肿,加快切口愈合,减轻伤口疼痛,从而减轻患者的痛苦,且经济、简单易行,无糖皮质激素样副作用,安全,无不良反应,值得临床推广应用。
Objective To investigate the therapeutic effect of sodium aescinate injection on edema after circumcision. Methods 150 cases of circumcision patients were randomly divided into treatment group and control group, 75 cases each. The control group after oral administration of matrine tablets 0.15 g orally, b.i.d., once a morning and evening, on the basis of routine dressing, anti-infective treatment, 7 d for a course of treatment. The patients in the treatment group were given routine dressing and anti-infective therapy after operation. At the same time, the treatment group started to use sodium aescinate 20 mg injections 10% glucose injection 250 ml intravenously once a day prior to the treatment group, qd, 7d for 1 course . No other anti-inflammatory and dehydration drugs were used in both groups. The patients were followed up for 2 weeks. The edema and the time of remission were recorded. Edema elimination time, mild, moderate and severe edema, wound healing and total effective rate at 7 days after operation were evaluated. Results The edema time of the treatment group was significantly shorter than that of the control group (P <0.01). The severity of edema in the treatment group was significantly lower than that of the control group (P <0.01), and the incision healing was significantly better than that of the control group (P <0.01) The effective rate was 96%, while the control group was 72%. The difference between the two groups was statistically significant (P <0.01). Conclusion Injection of sodium aescinate treatment of circumcision edema, rapid inhibition of exudation, eliminate foreskin edema, accelerate incision healing, reduce wound pain, thereby reducing the pain of patients, and the economy, simple, glucocorticoid-like Side effects, safety, no adverse reactions, it is worth clinical application.