论文部分内容阅读
目的:研究慢性肾小球疾病的血浆和尿血栓调节蛋白(PTM和UTM)水平及其临床意义。方法:用ELISA法检测PTM和UTM。结果:105例PTM水平中慢性肾小球肾炎(CGN,35.21±16.06μg/L)高于健康对照组(20.21±7.04μg/L),肾病综合征(NS,71.08±42.41μg/L)和慢性肾功能衰竭(CRF,126.21±60.39μg/L)又依次递增,疾病组之间比较均有显著性差异(P<0.01)。91例UTM结果相反,CGN(253.68±126.67μg/L)明显低于对照组(350.10±108.47μg/L),NS(159.23±86.93μg/L)和CR(93.08±61.82μg/L)又依次递增,各组间比较均有显著性差异(P<0.01)。相关分析发现PTM与BUN、Scr、血和尿β_2MG呈正相关(r=0.5926、0.478、0.5559和0.4409,P均<0.01),与Ccr呈负相关(r=0.6143,P<0.001);UTM与Ccr呈正相关(r=0.6988),与BUN、Scr和血β_2MG呈负相关(r=-0.5039、-0.3888、-0.6020,P均<0.05)。结论慢性肾小球疾病存在PTM和UTM的明显异常,并随疾病的严重度而PTM递增,DTM递减,认为检测TM可作为肾小球血管内皮损伤的敏感指标、并可判断肾功能损害的严重程度。
PURPOSE: To study the plasma and urinary thrombomodulin (PTM and UTM) levels and their clinical significance in chronic glomerular disease. Methods: PTM and UTM were detected by ELISA. Results: Chronic glomerulonephritis (CGN, 35.21 ± 16.06μg / L) in 105 PTM patients was significantly higher than that in healthy controls (20.21 ± 7.04μg / L), nephrotic syndrome (NS, 71.08 ± 42.41μg / L) Chronic renal failure (CRF, 126.21 ± 60.39μg / L) in turn increased, the disease groups were significantly different (P <0.01). The results of 91 cases of UTM showed that CGN (253.68 ± 126.67μg / L) was significantly lower than that of the control group (350.10 ± 108.47μg / L), NS (159.23 ± 86.93μg / L) and CR (93.08 ± 61.82μg / L) Increasing, there was a significant difference between the groups (P <0.01). Correlation analysis showed that PTM was positively correlated with BUN, Scr, blood and urine β_2MG (r = 0.5926,0.478,0.5559 and 0.4409, P <0.01), negatively correlated with Ccr (r = 0.6143, P <0.001) (R = 0.6988), which was negatively correlated with BUN, Scr and blood β_2MG (r = -0.5039, -0.3888, -0.6020, P <0.05). Conclusions There are obvious abnormalities of PTM and UTM in chronic glomerular diseases. With the severity of the disease, PTM increases and DTM decreases. It is considered that TM can be used as a sensitive index of glomerular endothelial injury and can judge the severity of renal dysfunction degree.