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采用间接酶联免疫吸附试验法（ＥＬＩＳＡ）和单克隆抗体间接免疫荧光法分别检测了３２例肾病综合征（肾病）患儿，２４例健康对照儿童血清和尿液ｓＩＬ２Ｒ浓度及外周血Ｔ细胞亚群百分率。结果表明，肾病活动期患儿血清及尿液ｓＩＬ２Ｒ浓度分别高于相应的缓解期患儿和健康对照儿童，且血清ｓＩＬ２Ｒ浓度的改变与其尿液ｓＩＬ２Ｒ浓度的改变呈正相关；肾病活动期患儿外周血ＣＤ４＋细胞百分率及ＣＤ４＋／ＣＤ８＋细胞比值明显低于缓解期患儿和健康对照儿童。提示肾病活动期患儿Ｔ细胞免疫应答能力降低，其血清及尿液ｓＩＬ２Ｒ浓度的改变可能与该疾病的发生发展有关
Indirect ELISA and indirect immunofluorescence were used to detect the serum and urinary sIL2R in 32 children with nephrotic syndrome (nephropathy) and 24 healthy children Cell subpopulation percentage. The results showed that children with active nephrotic serum and urine sIL 2R concentrations were higher than the corresponding children with remission and healthy children, and serum sIL 2R concentration changes and urine sIL 2R concentration changes was positively correlated; The percentage of CD4 + cells and the ratio of CD4 + / CD8 + cells in children with active nephropathy were significantly lower than those in children with remission and healthy control. Prompted nephrotic activity in children with T-cell immune response decreased serum and urine concentrations of sIL 2R may be related to the occurrence and development of the disease