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目的探讨血液病患者异基因造血干细胞移植(allogenichemopoieticstemcelltransplantation,Allo-HSCT)治疗后并发急性移植物抗宿主病(acutegraftanti-hostdisease,AGAHD)的腹部超声特点及其诊断价值。方法对43例Allo-HSCT患者进行常规腹部超声检查,以未发生AGAHD患者(10例)为对照组,分析发生AGAHD患者(33例)的声像学变化特征。结果AGAHD患者出现弥漫性肝实质损害、胆囊壁增厚、胆汁淤积、脾脏体积增大及肠蠕动异常等一系列变化均存在明显差异(P<0.05)。结论Allo-HSCT患者移植后的超声检查能够为AGAHD提供较为可靠的诊断依据。
Objective To investigate the characteristics and diagnostic value of abdominal ultrasonography in patients with hematological diseases after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) treated with acute graft-versus-host disease (AGAHD). Methods Forty-three patients with Allo-HSCT underwent routine abdominal ultrasonography. Patients without AGAHD (10 cases) were selected as the control group, and the changes of echocardiographic features of AGAHD patients (33 cases) were analyzed. Results There were significant differences in diffuse liver parenchyma, gallbladder wall thickening, cholestasis, enlarged spleen volume and abnormal peristalsis in AGAHD patients (P <0.05). Conclusion Allo-HSCT patients after transplantation ultrasound can provide a more reliable diagnosis of AGAHD.