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(一)延胡索素乙与环己烯巴比妥钠有协同作用,可以减低小白鼠的被动性和自发性活动;它能对抗小量苯丙胺的兴奋现象,又能明显降低大剂量苯丙胺的毒性反应。它们的有效剂量为20—40毫克/公斤。皮下注射乙素10—30毫克/公斤可使猫先兴奋后抑制,较大剂量对防御性条件反射和非条件反射均能抑制,该作用持续2—3小时以上;腹腔给药时作用情况相似。从侧脑室注射乙素1—2毫克/公斤可使猫消除恐惧跳避的行为,出现瞌睡现象,但易为外界刺激所唤醒。正常家兔的皮层脑电波以低电压快波为主,静脉注射乙素15—20毫克/公斤可使其变成高电压慢波,此时对感应电流刺激皮肤的惊醒反应明显消灭,约历40分钟乙素作用消失。 (二)乙素可使士的宁容易产生惊厥,伹能抑制五甲烯四氮唑的惊厥作用。它不能对抗电休克的发生,略能协同苯妥英钠作用。 (三)乙素略有中枢性的镇吐作用,略能降低体温。
(1) Cefosudin B has a synergistic effect with cyclohexene sodium, which can reduce the passive and spontaneous activity of mice; it can counteract the excitement of small amphetamines and can significantly reduce the toxicity of high-dose amphetamines . Their effective dose is 20-40 mg / kg. Subcutaneous injection of B 10-30 mg / kg cats can be excited after the first inhibition, the larger dose of defensive conditioning reflex and unconditional reflex can inhibit the effect lasts 2-3 hours; intraperitoneal administration similar to the role . Intracerebroventricular injection of 1-2 mg / kg of B can eliminate the fear of fear to avoid the cat behavior, drowsiness, but easy to wake up by external stimuli. Normal rabbit cortical brain waves to low-voltage fast wave-based, intravenous injection of 15-20 mg / kg B can make it into a high-voltage slow wave, then the induction current to stimulate the skin awakened reaction was significantly eliminated, calendar 40 minutes B-effect disappeared. (B) B can make strychnine easy to produce convulsions, 伹 can inhibit the pentylene tetrazole convulsions. It can not counter the occurrence of electric shock, a little synergistic effect of phenytoin sodium. (C) B slightly central central antiemetic effect, slightly lower body temperature.