遗传性非息肉性结直肠癌(H NPCC)家族成员年轻时易发生子宫内膜癌(EC)且多为子宫内膜样癌。H N PCC相关内膜癌常有微卫星不稳定性(M SI)。M SI和错配修复基因(M M R)蛋白表达缺失也可见于少数复杂性不典型增生(CA H)。采用M SI分析和免疫组化法及D N A测序方法检测50岁以下CAH Hepatic NPC members of the hereditary nonpolyposis colorectal cancer (H NPCC) family are predisposed to endometrial cancer (EC) and are mostly endometrioid carcinomas. H N PCC-associated endometrial cancer often has microsatellite instability (M SI). Loss of M SI and M M R protein expression can also be seen in a minority of atypical hyperplasias (CA H). MTH analysis and immunohistochemistry and D N A sequencing were used to detect CAH under 50 years of age