【摘 要】
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Herein,we report an efficient,tunable system for electrochemical reduction of ketones and phthalimides at room temperature with-out the need for stoichiometric external reductants.By utilizing NaN3 as the electrolyte and graphite felt as both the cathode
【机 构】
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State Key Laboratory Cultivation Base for TCM Quality and Efficacy,College of Pharmacy,Nanjing Unive
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Herein,we report an efficient,tunable system for electrochemical reduction of ketones and phthalimides at room temperature with-out the need for stoichiometric external reductants.By utilizing NaN3 as the electrolyte and graphite felt as both the cathode and the anode,we were able to selectively reduce the carbonyl groups of the substrates to alcohols,pinacols,or methylene groups by judi-ciously choosing the solvent and an acidic additive.The reaction conditions were compatible with a diverse array of functional groups,and phthalimides could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds.Mechanistic studies showed that the reactions involved electron,proton,and hydrogen atom transfers.Importantly,an N3/HN3 cycle operated as a hydrogen atom shuttle,which was critical for reduction of the carbonyl groups to methylene groups.
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