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近年来,随着一些有效致癌剂的应用,实验性大肠癌的研究发展较快。目前常用的致癌剂有1,2——二甲肼(DMH)、甲基硝基亚硝基胍(MNNG)、甲基硝基脲(MNU)等。八十年代初,Kamano T等用乙基硝基亚硝基胍(N-ethyl-N′-nitro-N-nitrosoguanidine,ENNG)栓剂诱发出狗大肠癌。但所复习的文献中尚未见用ENNG诱发小鼠大肠肿瘤的报道。作者用ENNG液给小鼠灌肠诱发了大肠和肛门肿瘤,并用组化方法对大肠腺癌的酶活性变化进行了观察,现将初步结果报道如下:
In recent years, with the application of some effective carcinogens, experimental colorectal cancer has developed rapidly. Currently used carcinogens include 1,2-dimethylhydrazine (DMH), methylnitrosoguanidine (MNNG) and methylnitrourea (MNU). In the early 1980s, Kamano T et al. induced neonatal colorectal cancer using suppositories of N-ethyl-N’-nitro-N-nitrosoguanidine (ENNG). However, reports of ENNG-induced murine colon tumors have not been reported in the reviewed literature. The authors enzymatically entomed the mice with ENNG solution to induce large intestine and anal tumours, and to observe changes in enzymatic activity of colorectal adenocarcinoma using histochemical methods. The preliminary results are now reported as follows: