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目的:探讨缩宫素与米索前列醇联合应用预防产后出血的疗效。方法:选取重庆市江津区第二人民医院妇产科2014年3月至2016年4月收治的自然分娩产妇212例,随机分为两组后进行对照研究,对照组106例给予宫缩素治疗,观察组106例给予宫缩素+米索前列醇治疗,对比两组产妇用药后的临床疗效。结果:同对照组比较,观察组第3产程时间短、产后平均失血量少,组间比较,差异具有统计学意义(P<0.05)。观察组产后出血发生率1.89%明显低于对照组10.38%,组间比较,差异具有统计学意义(P<0.05);不良反应情况:对照组18.87%,观察组2.83%,组间比较,差异具有统计学意义(P<0.05)。结论:缩宫素与米索前列醇联合应用,可显著降低产后出血发生,且用药安全性高。
Objective: To investigate the curative effect of oxytocin combined with misoprostol in preventing postpartum hemorrhage. Methods: 212 cases of natural childbirth admitted to Department of Obstetrics and Gynecology, Second People ’s Hospital of Jiangjin District, Chongqing from March 2014 to April 2016 were randomly divided into two groups and compared with 106 cases in control group , 106 cases of observation group were treated with orpisprost plus misoprostol, compared with the clinical efficacy of the two groups of maternal medication. Results: Compared with the control group, the observation group had shorter duration of the third stage of labor, less postpartum blood loss, and the difference between the two groups was statistically significant (P <0.05). The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group (1.89% vs 10.38%, P <0.05). The adverse reactions were 18.87% in the control group and 2.83% in the observation group. There was significant difference between the two groups Statistically significant (P <0.05). Conclusion: The combination of oxytocin and misoprostol can significantly reduce the incidence of postpartum hemorrhage, and the medication is safe.