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目的:研究N cadherin(神经性钙黏附分子)在非 小细胞肺癌组织中的表达及临床生物学意义.方法:常规石 蜡包埋切片行免疫组织化学检测90例非小细胞肺癌组织中 N cadherin的表达.结果:90例非小细胞肺癌组织中N cad herin表达阳性的例数为30例(33.3%);34例Ⅲ期患者中N cadherin阳性率47.06%,56例Ⅰ、Ⅱ期患者中N cadherin阳 性率25%,差异具有显著性意义(P<0.05).有淋巴结转移 的患者中N cadherin阳性率42.31%,无淋巴结转移的患者中 N-cadherin阳性率21.05%,差异具有显著性意义(P< 0.05).N cadherin在肺腺癌和鳞癌中的表达无显著性差异 (P>0.05).N cadherin在非小细胞肺癌组织中的表达与其分 期、淋巴结转移有关.结论:N cadherin可能参与非小细胞肺 癌侵袭和转移.
Objective: To study the expression and clinical significance of N-cadherin (non-small cell lung cancer) in non-small cell lung cancer.Methods: Immunohistochemistry was used to detect the expression of N-cadherin in 90 cases of non-small cell lung cancer .Results: The positive expression rate of N cadherin in 90 cases of non-small cell lung cancer was 30 cases (33.3%), the positive rate of N cadherin in 34 cases of stage Ⅲ was 47.06%, and in 56 cases of stage Ⅰ and Ⅱ N The positive rate of cadherin was 25%, the difference was significant (P <0.05) .The positive rate of N-cadherin in patients with lymph node metastasis was 42.31%, and the positive rate of N-cadherin in patients without lymph node metastasis was 21.05%, the difference was significant P <0.05) .Na cadherin expression in lung adenocarcinoma and squamous cell carcinoma had no significant difference (P> 0.05) .The expression of N-cadherin in non-small cell lung cancer and its staging, lymph node metastasis Off conclusion:. N cadherin may be involved in non-small cell lung cancer invasion and metastasis.