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目的探讨短期胰岛素泵强化治疗的T2DM患者血清铁(SI)变化与IR的关系。方法选取于我院内分泌科就诊的T2DM患者330例,行1周左右胰岛素泵治疗。记录血糖达标前、后时间段的SI、FPG和FC-P,将FPG、FC-P代人稳态模型公式2(HOMA2)计算IR。测定范围:FPG 3.0~25.0mmol/L,FC-P 0.6~10.5 ng/ml。结果强化治疗后FPG下降,SI、HOMA2-IR随之下降。Pearson相关分析显示,△SI与△HOMA2-IR呈正相关(t=24.191,P<0.01),与△HOMA2-β无相关性(P=0.505)。多元线性回归分析显示,△HOMA2-IR、BMI、网织红细胞血红蛋白含量(Ret-He)、强化治疗时间、年龄、HbA_1 c、病程是△SI的独立影响因素。结论T2DM患者经短期胰岛素泵强化治疗后SI下降,IR减少。
Objective To investigate the relationship between serum iron (SI) and IR in T2DM patients undergoing intensive insulin pump therapy. Methods Selected in our hospital endocrine department of treatment of 330 patients with T2DM, about 1 weeks of insulin pump treatment. The SI, FPG and FC-P in the pre-and post-glycemic periods were recorded. The FP and FC-P were used to calculate the IR of the steady-state model formula 2 (HOMA2). Measurement range: FPG 3.0 ~ 25.0mmol / L, FC-P 0.6 ~ 10.5 ng / ml. Results After intensive treatment FPG decreased, SI, HOMA2-IR decreased. Pearson correlation analysis showed that △ SI was positively correlated with △ HOMA2-IR (t = 24.191, P <0.01), but not with △ HOMA2-β (P = 0.505). Multivariate linear regression analysis showed that △ HOMA2-IR, BMI, Ret-He, duration of intensive treatment, age, HbA_1c, duration of disease were independent influencing factors of △ SI. Conclusions SI decreased and IR decreased in T2DM patients after short-term insulin pump therapy.