以自由基为代表的小分子活性物质对于维持生物体正常的生理功能起着不可或缺的作用,但在包括中风的多种病理状态下,过量的小分子活性物质由于其高活性、强氧化性可对人体内的组织器官造成严重损伤.活性氧和活性氮是两种重要的小分子活性物质,并且活性氮在中风的发病机制中的作用备受关注,是近年研究的热点之一.本文就近年来活性氮在中风中的生理性与病理性的作用进行综述及展望. Small molecule actives represented by free radicals play an indispensable role in maintaining the normal physiological functions of an organism. However, in various pathological states including stroke, excess small molecule active substances are strongly oxidized due to their high activity Sex can cause serious damage to the tissues and organs of the human body.Radioactive oxygen and reactive nitrogen are two important small molecule active substances, and the active nitrogen has drawn much attention in the pathogenesis of stroke, which is one of the hot spots in recent years. In this paper, the physiological and pathological roles of reactive nitrogen in stroke in recent years are summarized and prospected.