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石吊兰素混悬剂大鼠肠袢或灌胃给药吸收甚差;溶液剂肠袢注入后吸收快而完全,但灌胃后吸收不良。静脉注射后5分钟以肝脏、血浆含量最高,淋巴、肺、心、脑、肾、脾次之,脂肪、肌肉、睾丸最低。按平衡透析法测得本品血浆蛋白结合率为51.3±2.2％((?)±SD,下同)。本品可经尿、粪和胆汁排泄。石吊兰素体内代谢旺盛,尿中除其葡萄糖醛酸结合物及硫酸结合物外,尚发现一种极性较大的石吊兰素代谢产物。 狗静脉恒速滴注石吊兰素后的血浆药物浓度与其降压效应之间基本呈平行关系,不同狗的最大降压效应与该时血浆药物浓度密切相关。
The dose of sparulase suspension in rats is poorly absorbed in the gut or gavage; the solution is absorbed quickly and completely after the gut injection in the solution, but it is absorbed badly after gavage. 5 minutes after intravenous injection to the liver, the highest plasma content, lymph, lung, heart, brain, kidney, spleen, fat, muscle, testis lowest. According to the balance dialysis method measured plasma protein binding rate of 51.3 ± 2.2% ((?) SD, the same below). This product can be excreted by urine, excrement and bile. Stone spider hormone in vivo metabolism, urine in addition to its glucuronic acid conjugates and sulfate conjugates, still found a greater polarity of the metabolite of spain. The dog plasma intravenous constant dose of heparadin after plasma drug concentration and its antihypertensive effect was basically parallel to the relationship between the different dogs the maximum antihypertensive effect and the plasma concentration of the drug is closely related.