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外科手术可致体温升高、血沉增快和急相蛋白增加,其原因尚不清楚。外科干扰所致的无菌性炎症可能与其发生有关。最近发现不同组织中白细胞介素6(IL-6)有多种功能,特别是在B细胞、肝细胞和其它细胞中能诱导免疫球蛋白和急相蛋白产生。Nijsten等指出严重烧伤病人血清IL-6增加,提出IL-6在急性排斥和炎症反应时的重要作用。为了解IL-6在手术后炎症中的作用,作者对术后病人的IL-6和急相蛋白进行了研究。对胆囊息肉、胆总管结石和早期胃癌的3例病人分别作切除术,术前病人无炎症反应,术后检测IL-6和急相蛋白[C反应蛋白(CRP)、
Surgery can cause elevated body temperature, erythrocyte sedimentation rate and rapid increase in protein, the reason is not clear. Aseptic inflammation due to surgical interference may be related to its occurrence. Recently, interleukin 6 (IL-6) has been shown to function in a variety of tissues, particularly immunoglobulins and acute phase proteins in B cells, hepatocytes and other cells. Nijsten pointed out that serum IL-6 in severe burn patients increased, suggesting that IL-6 plays an important role in acute rejection and inflammation. To understand the role of IL-6 in postoperative inflammation, the authors studied postoperative IL-6 and acute phase proteins. Three patients with gallbladder polyps, common bile duct stones and early gastric cancer were treated with resection and no inflammatory reaction before operation. The levels of IL-6 and CRP,