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α-氨基-3-羟基-5-甲基-4-异唑-丙酸(AMPARs)是调节快速突触传递的兴奋性谷氨酸受体,是由GluR1、GluR2、GluR3和GluR4四种亚基选择性组装构成同源或异源四聚物。GluR2亚基对AMPARs的特性有重要影响,含GluR2亚基的AMPARs对Ca2+不通透,中枢神经系统中大多数AMPARs为此类;不含GluR2亚基的AMPARs对Ca2+有较好的通透性,这类AMPARs在限定的神经元或特定的生理或病理条件下表达。近年来的研究发现,GluR2缺失的AMPARs对突触功能、突触可塑性、神经局部环路传导等有特殊的作用。本文对GluR2缺失的AMPARs及其对突触功能和可塑性的作用作一综述。
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPARs) is an excitatory glutamate receptor that regulates rapid synaptic transmission and consists of four subtypes of GluR1, GluR2, GluR3 and GluR4 The base is selectively assembled to form homologous or heteromeric tetramers. The GluR2 subunit has an important effect on the properties of AMPARs. AMPARs containing GluR2 subunit are not permeable to Ca2 +, and most AMPARs in the central nervous system are of this type. AMPARs without GluR2 subunit have better permeability to Ca2 + Such AMPARs are expressed in defined neurons or under specific physiological or pathological conditions. Recent studies have found that GluAR2-deficient AMPARs have special effects on synaptic function, synaptic plasticity, and local neural circuit conduction. This review summarizes the role of GluR2-deficient AMPARs in synaptic function and plasticity.