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目的:研究成人原发肾病综合征(PNS)患者高尿酸血症的患病率及其与血脂代谢的关系。方法:将109例成人PNS患者根据其尿酸水平分为高尿酸血症组与血尿酸正常组,检测患者的血脂、血清脂蛋白、ALB及24小时尿蛋白定量,分析成人PNS患者高尿酸血症的患病率,比较高尿酸血症组与血尿酸正常组PNS患者的一般情况及血脂水平,并分析PNS患者血尿酸水平的相关因素。结果:成人PNS患者高尿酸血症的发病率为24.77%;高尿酸血症组患者TG及24小时尿蛋白定量水平明显高于血尿酸正常组(P<0.01),两组患者TC、LDL-C、HDL-C、Apo AI及Apo B比较差异无统计学意义(P>0.05);成人PNS患者血尿酸水平与TG及24小时尿蛋白定量水平呈正相关(r=0.350,P=0.001;r=0.533,P=0.014),与TC、LDL-C、HDL-C及ALB无明显相关性(P>0.05)。结论:成人PNS患者高尿酸血症的发生率较高,高尿酸血症患者具有更高的TG及尿蛋白水平,且成人PNS患者血尿酸水平与TG及24小时尿蛋白定量具有相关性,应高度重视成人PNS患者的血尿酸水平。
Objective: To study the prevalence of hyperuricemia in adults with primary nephrotic syndrome (PNS) and its relationship with lipid metabolism. Methods: 109 cases of adult PNS patients were divided into hyperuricemia group and normal uric acid group according to the level of uric acid. Serum lipids, serum lipoprotein, ALB and 24-hour urinary protein were measured in patients with hyperuricemia The prevalence of hyperuricemia in patients with hyperuricemia and serum uric acid in patients with PNS general situation and blood lipid levels, and analysis of serum creatinine levels in PNS patients related factors. Results: The incidence of hyperuricemia in adults with PNS was 24.77%. The levels of TG and 24-hour urinary protein in patients with hyperuricemia were significantly higher than those with normal serum uric acid (P <0.01). TC and LDL- C, HDL-C, Apo AI and Apo B had no significant difference (P> 0.05). The level of serum uric acid in adults with PNS was positively correlated with the levels of TG and 24-hour urinary protein (r = 0.350, = 0.533, P = 0.014), no significant correlation with TC, LDL-C, HDL-C and ALB (P> 0.05). Conclusion: The incidence of hyperuricemia in adult patients with PNS is high, patients with hyperuricemia have higher levels of TG and urine protein, and serum uric acid levels in patients with PNS have a correlation with TG and 24-hour urinary protein. Attaches great importance to adult patients with PNS serum uric acid levels.