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目的：比较不同剂量辛伐他汀对高脂血症患者的调脂作用。方法： 43例高脂血症患者随机分为两组，分别接受 10mg/d(A组 )和 20mg/d(B超 )辛伐他汀治疗，服药前及服药后 8w测定血脂。结果： (1)用药 8w后两组中总胆固醇 (TC)及低密度脂蛋白胆固醇 (LDL-C)水平较治疗前均有明显降低。 (2)B组中甘油三酯 (TG)水平明显降低 (P<0. 05)，高密度脂蛋白胆固醇 (HDL-C)明显升高 (P<0. 01)，而在 A组 TG及 HDL水平则无明显变化。 (3)两组治疗 8w后脂蛋白 (a)[LP(a)]水平与治疗前比较均明显降低 (P<0. 05)。 (4)两组降低血脂的有效率分别为 68. 75％和 90. 32％，两者比较有明显差异 (P<0. 01)。结论：辛伐他汀每天 20mg才能达到满意的调脂效果。
Objective: To compare the effects of different doses of simvastatin on hyperlipidemia in patients with lipid-lowering effect. Methods: Forty-three patients with hyperlipidemia were randomly divided into two groups: 10 mg / d (group A) and 20 mg / d (b-mode) simvastatin respectively. Serum lipids were measured before and 8 weeks after taking the drug. Results: (1) After 8 weeks of treatment, the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in both groups were significantly lower than those before treatment. (2) In group B, triglyceride (TG) level was significantly lower (P <0.05) and HDL-C was significantly higher (P <0.01) HDL levels did not change significantly. (3) The level of lipoprotein (a) [LP (a)] in both groups after 8w treatment was significantly lower than that before treatment (P <0.05). (4) The effective rates of lowering blood lipid in the two groups were 68.75% and 90.32%, respectively, with significant differences between the two groups (P <0.01). Conclusion: Simvastatin 20mg per day to achieve satisfactory lipid-lowering effect.