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桥本甲状腺炎是一种常见的慢性自身免疫性疾病,表现为辅助性T细胞(Th)1占优势。 Th1类细胞因子白细胞介素(IL)-12表达增加,在该病的诱发及慢性迁延中起重要作用,Th2类细胞因子IL-10表达的下调也与该病有关,且随病情变化二者表达水平有所不同。因此,这些细胞因子可作为病情变化的监测指标,并且可通过调节细胞因子的表达水平从而使失衡的Th1／Th2细胞趋于平衡。这可能为桥本甲状腺炎的治疗开拓一条新途径。
Hashimoto’s thyroiditis is a common chronic autoimmune disease characterized by the predominance of helper T cells (Th) 1. Th1 type cytokines interleukin (IL) -12 expression increased in the induction of disease and chronic delay play an important role in the Th2 cytokines IL-10 expression is also associated with the disease, and both changes with the condition The level of expression is different. Therefore, these cytokines can be used as indicators of disease progression, and the unbalanced Th1 / Th2 cells can be balanced by regulating the expression of cytokines. This may open a new way for the treatment of Hashimoto’s thyroiditis.