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目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者脉压的变化。方法选择OSAHS患者85例,均采用多导睡眠图仪(PSG)监测及测量其血压,计算出脉压、平均收缩压及平均舒张压,同时计算体重指数。结果85例OSAHS患者中有35例合并存在高血压,约占总数的41%。OSAHS合并高血压组患者的呼吸紊乱指数明显高于单纯OSAHS患者,OSAHS合并高血压组患者的最低血氧饱和度以及平均血氧饱和度均低于单纯OSAHS患者,而其脉压及体重指数则明显高于单纯OSAHS患者。重度OSAHS患者的脉压、体重指数、平均收缩压及平均舒张压均明显高于轻、中度OSAHS患者,而轻、中OSAHS患者之间差异无统计学意义。相关分析结果表明,呼吸紊乱指数与脉压、平均收缩压、平均舒张压呈正相关,与最低氧饱和度呈负相关,与体重指数、平均氧饱和度无相关性。结论脉压与OSAHS的严重程度密切相关,且是预测OSAHS并发高血压心血管事件的重要预报因子。
Objective To investigate the changes of pulse pressure in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Eighty-five OSAHS patients were selected. The polysomnography (PSG) was used to monitor and measure the blood pressure. The pulse pressure, mean systolic pressure and mean diastolic pressure were calculated. Body mass index was also calculated. Results In 85 patients with OSAHS, 35 patients had hypertension, accounting for 41% of the total. OSAHS patients with hypertension group were significantly higher than those with OSAHS patients with OSAHS, OSAHS patients with hypertension and the lowest oxygen saturation and mean oxygen saturation were lower than those in patients with OSAHS alone, and its pulse pressure and body mass index Obviously higher than simple OSAHS patients. Pulse pressure, body mass index, mean systolic pressure and mean diastolic pressure in patients with severe OSAHS were significantly higher than those in patients with mild and moderate OSAHS, but there was no significant difference between OSAHS patients with mild and moderate OSAHS. Correlation analysis showed that the index of respiratory disorders was positively correlated with pulse pressure, mean systolic pressure and mean diastolic pressure, negatively correlated with lowest oxygen saturation, and no correlation with body mass index and mean oxygen saturation. Conclusions Pulse pressure is closely related to the severity of OSAHS and is an important predictor of cardiovascular events in patients with OSAHS complicated by hypertension.