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目的:探讨表皮生长因子受体-2(cerbB-2)在鼻咽癌组织中的表达情况及其意义。方法:采用免疫组织化学SP法检测cerbB-2在90例鼻咽癌组织和22例鼻咽炎性组织中的表达情况,分析cerbB-2表达水平与鼻咽癌临床病理因素的关系。结果:90例鼻咽癌组织中cerbB-2表达的阳性率为65.56%,22例鼻咽炎性组织中cerbB-2表达的阳性率为31.82%(P<0.05);鼻咽癌组CerbB-2表达在淋巴结分期N_2和N_3患者中阳性率为81.0%,N_0和N_1患者阳性率为52.1%(P<0.05),而与患者年龄、性别、临床分期、T分期和远处转移无明显相关(P>0.05)。结论:CerbB-2在鼻咽癌组织中高表达,它可能是鼻咽癌发生和发展过程中的一个重要因素。
Objective: To investigate the expression of epidermal growth factor receptor-2 (cerbB-2) in nasopharyngeal carcinoma and its significance. Methods: Immunohistochemical SP method was used to detect the expression of cerbB-2 in 90 cases of nasopharyngeal carcinoma and 22 cases of nasopharyngitis tissues. The relationship between the expression of cerbB-2 and the clinicopathological factors of nasopharyngeal carcinoma was analyzed. Results: The positive rate of cerbB-2 in 90 cases of nasopharyngeal carcinoma was 65.56%, and the positive rate of cerbB-2 in 22 cases of nasopharyngeal tissues was 31.82% (P <0.05). The positive rate of CerbB-2 The positive expression rate was 81.0% in patients with N 2 and N 3 lymph nodes. The positive rates of N 0 and N 1 in patients with lymph node metastasis were 52.1% (P <0.05), but not with age, sex, clinical stage, T stage and distant metastasis P> 0.05). Conclusion: CerbB-2 is highly expressed in nasopharyngeal carcinoma, which may be an important factor in the occurrence and development of nasopharyngeal carcinoma.