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目的 :探讨癌基因 P2 1和抑癌基因 P16的表达与膀胱癌生物学行为之间的关系。方法 :采用免疫组织化学 S- P法对 40例膀胱移行细胞癌癌基因 P2 1和抑癌基因 P16进行检测。结果 :P2 1和 P16阳性表达率为 67.5 %和 5 2 .5 % ;P2 1阳性表达率与膀胱移行细胞癌的病理分级和临床分期呈正相关 ,而 P16阳性表达率与膀胱移行细胞癌的病理分级和临床分期呈负相关。结论 :P2 1、P16基因蛋白的表达与膀胱肿瘤组织病理分级、临床分期密切相关 ;膀胱肿瘤的发生与癌基因的激活、抑癌基因的失活的协同作用有关
Objective: To investigate the relationship between the expression of oncogene P2 1 and tumor suppressor gene P16 and the biological behavior of bladder cancer. Methods: The expressions of oncogene P2 1 and tumor suppressor gene P16 in transitional cell carcinoma of bladder (TCC) were detected by immunohistochemical S-P method. Results: The positive rates of P2 1 and P16 were 67.5% and 52.5% respectively. The positive rate of P2 1 was positively correlated with the pathological grade and clinical stage of transitional cell carcinoma of the bladder. The positive rate of P16 was correlated with the pathological changes of bladder transitional cell carcinoma Grading and clinical stage was negatively correlated. Conclusion: The expression of P2 1, P16 protein is closely related to the histological grade and clinical stage of bladder neoplasm. The occurrence of bladder neoplasm is related to the synergistic effect of oncogene activation and tumor suppressor gene inactivation