Obiective:To study the therapeutic effect of Weicao Capsule(威草胶囊,WCC)on gout.Methods:Two hundred gout patients were assigned to two groups.The treated group was groups were given the respective treatments orally 3 times a day,2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment.Changes of blood β2-microglobulin(β2-M),hemoglobin(Hb),24 h urinary protein(24 h UP),pH value of urine and blood uric acid(BUA)as well as kidney function were observed.Results:After treatment,IeveI of β2-M got lowered significantly,Hb and 24 h UP,blood urea nitrogen,serum creatinine and the clearance rate of creatinine,as well as blood lipids all improved obviously in the treated group(all P＜0.01),while these parameters remained unchanged in the control group (P＞0.05).The pH value of urine was improved in both groups showing an insignificant difference between them(P＞0.05).BUA was decreased in both groups with a decrease to a larger extent in the treated group(P＜0.01).The total effective rate was 87% in the treated group,which was superior to that in the control group(62%,P＜0.05).Conclusion:WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M,BUA and lipids.